Potassium Hydroxide → HCID 58345430, compound

HRID 1877977Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([S:19][C:20]([F:23])([F:22])[F:21])[CH:14]=3)=[CH:11][C:10]([C:24]([O:26]CC)=[O:25])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[OH-].[K+]>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([S:19][C:20]([F:22])([F:23])[F:21])[CH:14]=3)=[CH:11][C:10]([C:24]([OH:26])=[O:25])=[N:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 58345399HCID 58345399, compound

Product 1

HCID 58345430HCID 58345430, compoundYield 87%

Procedure

Starting from 850 mg (1.99 mmol) of ethyl 1-(3-chlorophenyl)-5-{3-[(trifluoromethyl)thio]phenyl}-1H-pyrazole-3-carboxylate from example 5A and 1.12 g (19.9 mmol) of potassium hydroxide, 691.5 mg (1.7 mmol, 87% yield of theory) are obtained as crystals according to the method described in example 7A.

Workup

customare obtained as crystals

Sources & evidence

ORD record: ord-7b6ff00beed2435a8175b08937974aac
Source dataset: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08314089B2

Reaction notes

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