Potassium Hydroxide → HCID 58277445, compound

HRID 1877978Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:23])([F:22])[F:21])[CH:14]=3)=[CH:11][C:10]([C:24]([O:26]CC)=[O:25])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[OH-].[K+]>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:23])([F:22])[F:21])[CH:14]=3)=[CH:11][C:10]([C:24]([OH:26])=[O:25])=[N:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 58277354HCID 58277354, compound

Product 1

HCID 58277445HCID 58277445, compoundYield 95%

Procedure

Starting from 1.9 g (4.63 mmol) of ethyl 1-(3-chlorophenyl)-5-[3-(trifluoromethoxy)phenyl]-1H-pyrazole-3-carboxylate from example 6A and 2.59 g (46.25 mmol) of potassium hydroxide, 1.68 g (4.4 mmol, 95% yield of theory) are obtained as crystals according to the method described in example 7A.

Workup

customare obtained as crystals

Sources & evidence

ORD record: ord-7a728cf2b1dd4ff69658d9d6b20431ac
Source dataset: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08314089B2

Reaction notes

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