Potassium Hydroxide → HCID 58345395, compound

HRID 1877984Notes

Reaction equation

HRID 1877984 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=3)=[CH:11][C:10]([C:23]([O:25]CC)=[O:24])=[N:9]2)=[CH:4][CH:3]=1.[OH-].[K+]>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:20])[F:21])[CH:14]=3)=[CH:11][C:10]([C:23]([OH:25])=[O:24])=[N:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 58345429HCID 58345429, compound

Product 1

HCID 58345395HCID 58345395, compoundYield 80%

Procedure

Starting from 450 mg (1.2 mmol) of ethyl 1-(4-methylphenyl)-5-[3-(trifluoro-methyl)phenyl]-1H-pyrazole-3-carboxylate from example 15A and 135 mg (2.4 mmol) of potassium hydroxide, 334.7 mg (0.97 mmol, 80% yield of theory) are obtained as crystals according to method described in example 7A.

Workup

  1. customare obtained as crystals

Sources & evidence

ORD record
ord-3da661a7d3114ba78c9a75cd87d74607
Source dataset
uspto-grants-2012_11
Patent number
US08314089B2

Reaction notes

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