Potassium Hydroxide → HCID 58345400, compound

HRID 1877985Notes

Reaction equation

HRID 1877985 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([C:19]#[N:20])[CH:14]=3)=[CH:11][C:10]([C:21]([O:23]CC)=[O:22])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[OH-].[K+]>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([C:19]#[N:20])[CH:14]=3)=[CH:11][C:10]([C:21]([OH:23])=[O:22])=[N:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 58345403HCID 58345403, compound

Product 1

HCID 58345400HCID 58345400, compoundYield 94%

Procedure

Starting from 2.75 g (7.82 mmol) of ethyl 1-(3-chlorophenyl)-5-(3-cyanophenyl)-1H-pyrazole-3-carboxylate from example 16A and 4.39 g (78.2 mmol) of potassium hydroxide, 2.37 mg (7.3 mmol, 94% yield of theory) are obtained as crystals according to the method described in example 7A.

Workup

  1. customare obtained as crystals

Sources & evidence

ORD record
ord-02ec9f1c61cc44ac90ffee8a33398bad
Source dataset
uspto-grants-2012_11
Patent number
US08314089B2

Reaction notes

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