Potassium Hydroxide → HCID 58345424, compound

HRID 1877989Notes

Reaction equation

HRID 1877989 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-:21])=[O:20])[CH:14]=3)=[CH:11][C:10]([C:22]([O:24]CC)=[O:23])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[OH-].[K+]>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-:21])=[O:20])[CH:14]=3)=[CH:11][C:10]([C:22]([OH:24])=[O:23])=[N:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 58345440HCID 58345440, compound

Product 1

HCID 58345424HCID 58345424, compoundYield 92%

Procedure

Starting from 400 mg (1.1 mmol) of ethyl 1-(3-chlorophenyl)-5-(3-nitrophenyl)-1H-pyrazole-3-carboxylate from example 20A and 603 mg (10.7 mmol) of potassium hydroxide, 340.5 mg (0.99 mmol, 92% yield of theory) are obtained as crystals according to the method described in example 7A.

Workup

  1. customare obtained as crystals

Sources & evidence

ORD record
ord-5b0451f4b88e4311a8d0e68a9a5aed8d
Source dataset
uspto-grants-2012_11
Patent number
US08314089B2

Reaction notes

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