Potassium Hydroxide → HCID 58345435, compound

HRID 1877990Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[C:13]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=3)=[CH:12][C:11]([C:24]([O:26]CC)=[O:25])=[N:10]2)[CH:6]=[CH:7][CH:8]=1.[OH-].[K+]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[C:13]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:21])([F:22])[F:23])[CH:15]=3)=[CH:12][C:11]([C:24]([OH:26])=[O:25])=[N:10]2)[CH:6]=[CH:7][CH:8]=1

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 58345415HCID 58345415, compound

Product 1

HCID 58345435HCID 58345435, compoundYield 72%

Procedure

Starting from 1.6 g (4.1 mmol) of ethyl 1-(3-methoxyphenyl)-5-[3-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylate from example 21A and 2.3 g (41 mmol) of potassium hydroxide, 1.07 g (2.9 mmol, 72% yield of theory) are obtained as crystals according to the method described in example 7A.

Workup

customare obtained as crystals

Sources & evidence

ORD record: ord-3afc2a19d78348f5b43bcbe938bbb494
Source dataset: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08314089B2

Reaction notes

Loading…