Oxygen → HCID 58345426, compound

Participants

Reaction Steps

Under exclusion of oxygen, 5 ml of dichloromethane and 1 ml of trifluoroacetic acid were added to 140 mg (0.25 mmol) of tert-butyl 4-{[1-(3-chlorophenyl)-5-(3-trifluoromethoxy-phenyl)-1H-pyrazol-3-yl]carbonyl}piperazine-1-carboxylate, prepared from the compound of example 9A and tert-butyl piperazine-1-carboxylate in analogy to example 1, and the mixture is stirred for 12 hours at room temperature. The reaction mixture is diluted with dichloromethane and washed with a sodium bicarbonate solution and a sodium chloride solution. The organic phase is dried over sodium sulfate and concentrated on a rotary evaporator. 101 mg (88% yield of theory) of product are obtained. By thorough drying in high vacuum at 60° C. an analytical sample is freed of solvent residues.

Provenance & Evidence