Triethylamine → HCID 25254413, compound

Participants

Reaction Steps

To a stirred solution of [6-chloro-2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methylamine hydrochloride (60 mg, 0.20 mmol) in THF (1 mL), triethylamine (66 μL, 0.47 mmol) and 4-fluorophenyl isocyanate (32 mg, 0.24 mmol) were sequentially added at room temperature. The reaction solution was stirred overnight at room temperature and then concentrated. The residue was purified by thin-layer silica gel column chromatography (ethyl acetate/hexane=1/1), whereby the objective compound (24 mg, 28%) was obtained as a white solid.

Provenance & Evidence