Hexane → HCID 68490644, Verbindung

HRID 1878010Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1878010
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:10][C:9](=[O:11])[O:8][C:7]([CH2:16][NH:17][C:18]([NH:20][C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=3)=[O:19])([C:12]([F:15])([F:14])[F:13])[C:6]=2[CH:28]=1.CCCCCC>CC(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:10][C:9](=[O:11])[O:8][C@@:7]([CH2:16][NH:17][C:18]([NH:20][C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=3)=[O:19])([C:12]([F:14])([F:15])[F:13])[C:6]=2[CH:28]=1

Komponenten

4

Edukt 2

HCID 8058HexaneHCID 25254413HCID 25254413, Verbindung

Produkt 1

HCID 68490644HCID 68490644, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

N-{[6-chloro-2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}-N′-(4-fluorophenyl)urea was subjected to optical resolution by HPLC (Chiralpack AD-H, n-hexane:2-propanol=3:1), and a fraction eluted at a later time was concentrated, whereby the objective compound was obtained.

Aufarbeitung

  1. washa fraction eluted at a later time
  2. concentrationwas concentrated
  3. customwhereby the objective compound was obtained

Quellen und Nachweise

ORD-Eintrag
ord-b66f2babfcbb4ed087bb1103bdab4781
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08314094B2

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