Morpholine → HCID 178513345, compound

HRID 1878051Notes

Reaction equation

HRID 1878051 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:7]=[N:8][C:9]([C:12](=[N:14][OH:15])[NH2:13])=[CH:10][CH:11]=1)=[O:4].[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>O>[OH:15][NH:14][C:12]([C:9]1[N:8]=[CH:7][C:6]([NH:5][C:3](=[O:4])[CH2:2][N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)=[CH:11][CH:10]=1)=[NH:13]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 137068883HCID 137068883, compound

Product 1

HCID 178513345HCID 178513345, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Compound of example 4 (0.10 g, 0.44 mmol) was stirred in morpholine (1 mL) at 25 ° C. for 2 hours. The reaction mixture was then diluted with water and extracted with chloroform (2×50 mL), followed by extraction with ethyl acetate (2×50 mL). Both organic layers were dried over anhydrous sodium sulfate and concentrated. The crude product obtained was purified using column chromatography (silica gel, 1% methanol in chloroform as an eluent) to obtain the title compound.

Workup

  1. extractionextracted with chloroform (2×50 mL)
  2. extractionfollowed by extraction with ethyl acetate (2×50 mL)
  3. dry with materialBoth organic layers were dried over anhydrous sodium sulfate
  4. concentrationconcentrated
  5. customThe crude product obtained
  6. customwas purified

Sources & evidence

ORD record
ord-d3bd296f1474463899ef753448f793bf
Source dataset
uspto-grants-2012_11
Patent number
US08314103B2

Reaction notes

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