Chloroacetyl chloride → HCID 67050365, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 2-amino-5-cyanopyridine (2.0 g, 16.8 mmol) in dry chloroform (40 mL) was added triethylamine (2.54 g, 25.21 mmol) with stirring at 0° C. To the reaction mixture chloroacetyl chloride (2.08 g, 18.48 mmol) was added dropwise, and stirred at 0° C. for 1 hour and then at room temperature for 12 hours. The reaction mixture was diluted with chloroform (100 mL) and washed with water (150 mL). The organic layer was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The product was recrystallized from chloroform and petroleum ether to obtain the title compound.

Provenance & Evidence