Acetic Anhydride → HCID 25184842, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of compound of example 1 (0.2 g, 1.32 mmol) in acetic acid was added acetic anhydride (0.202 g, 1.98 mmol) and the reaction mixture was stirred at a temperature of 25° C. for 5 minutes. To the reaction mixture, 10% Pd/C (0.028 g) was added and shaken with hydrogen on Parr hydrogenation apparatus at a pressure of about 15 psi for a period of 4 hours. The reaction mixture was filtered through celite and the filter pad was washed with glacial acetic acid (15 mL). The filtrate was combined and acid removed under reduced pressure. The traces of acid were removed by using petroleum ether and the solid obtained was purified by column chromatography using silica gel and 10% methanol/chloroform as eluent to obtain the title compound.

Provenance & Evidence