Ethyl 2-methylacetoacetate → HCID 178474096, compound

Participants

Reaction Steps

To a solution of compound of example 44 (0.01 g, 0.56 mmol) in water (2 mL) and ethanol (1 mL) was added ethyl 2-methyl-3-oxobutanoate (0.013 g, 0.89 mmol) and sodium carbonate (0.0107 g, 1.011 mmol) and the reaction mixture was stirred at room temperature for 26 hours. Ethanol was removed under reduced pressure, and the reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated to obtain the crude product, which was purified by column chromatography using silica gel and 1% methanol in chloroform as an eluent to obtain the title compound.

Provenance & Evidence