Chloroacetyl chloride → HCID 178520803, compound

Participants

Reaction Steps

To a solution of compound of example 49 (0.40 g, 0.16 mmol) in THF (4 mL) at 0° C. was added triethylamine (0.025 g, 0.25 mmol) and chloroacetylchloride (0.0285 g, 0.25 mmol), and the reaction mixture was stirred at room temperature for 30 minutes. THF was removed under reduced pressure, and reaction mixture was quenched with water and extracted with ethyl acetate (3×10 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated to obtain the crude product, which was purified by column chromatography using silica gel and 1% methanol in chloroform as an eluent to obtain the title compound.

Provenance & Evidence