1-(2-Methoxyphenyl)piperazine → HCID 11509806, compound

HRID 1878100Notes

Reaction equation

HRID 1878100 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([O:12][CH3:13])[C:6]([NH:14][C:15](=[O:19])OCC)=[N:5]2.[CH3:20][O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([O:12][CH3:13])[C:6]([NH:14][C:15]([N:31]1[CH2:30][CH2:29][N:28]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[O:21][CH3:20])[CH2:33][CH2:32]1)=[O:19])=[N:5]2

Participants

3

Reactant 2

HCID 13461-(2-Methoxyphenyl)piperazineHCID 66917965Ethyl N-(6-fluoro-2-methoxyquinoxalin-3-yl)carbamate

Product 1

HCID 11509806HCID 11509806, compoundYield 84%

Procedure

Ethyl N-(6-fluoro-2-methoxyquinoxalin-3-yl)carbamate and 1-(2-methoxyphenyl)piperazine were reacted by the same way with the example 1 to obtain the titled compound (yield, 84%). 1H NMR (200 MHz, CDCl3): δ 3.15 (s, 4H), 3.79-3.87 (m, 6H), 4.11 (s, 4H), 6.86-7.02 (m, 4H), 7.18-7.22 (m, 1H), 7.39-7.50 (m, 1H), 7.65-7.72 (m, 1H).

Sources & evidence

ORD record
ord-10e9fe78994e495e866bb0fd1295f5f9
Source dataset
uspto-grants-2012_11
Patent number
US08314100B2

Reaction notes

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