HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Pyrimidinyl)piperazine → 1-[(6-Chloro-2-methoxyquinoxalin-3-yl)aminocarbonyl]-4-(2-pyrimidyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Pyrimidinyl)piperazine | HCID 88747 | — |
| Reactant | Ethyl N-(6-chloro-2-methoxyquinoxalin-3-yl)carbamate | HCID 66918182 | — |
| Product | 1-[(6-Chloro-2-methoxyquinoxalin-3-yl)aminocarbonyl]-4-(2-pyrimidyl)piperazine | HCID 66917991 | 90% |
Reaction Steps
Ethyl N-(6-chloro-2-methoxyquinoxalin-3-yl)carbamate and 1-(2-pyrimidyl)piperazine were reacted by the same way with the example 22 to obtain the titled compound (yield, 90%). 1H NMR (300 MHz, CDCl3): δ 3.71 (s, 4H), 3.99 (s, 3H), 4.15 (s, 4H), 6.55 (s, 1H), 7.27-7.43 (m, 2H), 7.66 (s, 1H), 7.80 (s, 1H), 8.35 (s, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08314100B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-551c225e8b224f8599b2244d212e147d |
| Source note | uspto-grants-2012_11 |