2-Mepp → 1-[(2-Methoxy-6-methylquinoxalin-3-yl)aminocarbonyl]-4-(2-methylphenyl)piperazine

HRID 1878148Notes

Reaction equation

HRID 1878148 reaction equation
[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14](=[O:18])OCC)=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:19])[CH:9]=2)[N:4]=1.[CH3:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14]([N:30]2[CH2:31][CH2:32][N:27]([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[CH3:20])[CH2:28][CH2:29]2)=[O:18])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:19])[CH:9]=2)[N:4]=1

Participants

3

Reactant 2

HCID 919652-MeppHCID 66917958Ethyl N-(2-methoxy-6-methylquinoxalin-3-yl)carbamate

Product 1

HCID 669180851-[(2-Methoxy-6-methylquinoxalin-3-yl)aminocarbonyl]-4-(2-methylphenyl)piperazineYield 95%

Procedure

Ethyl N-(2-methoxy-6-methylquinoxalin-3-yl)carbamate and 1-(2-methylphenyl)piperazine were reacted by the same way with the example 43 to obtain the titled compound (yield, 95%). 1H NMR (300 MHz, CDCl3): δ 2.32-2.56 (m, 6H), 2.88-3.00 (m, 4H), 3.77 (s, 3H), 4.08-4.13 (m, 4H), 7.02-7.04 (m, 3H), 7.19-7.39 (m, 3H), 7.51-7.65 (m, 2H).

Sources & evidence

ORD record
ord-bd941437f6694fd39abef61d6dd49b0c
Source dataset
uspto-grants-2012_11
Patent number
US08314100B2

Reaction notes

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