反应详情

3-Amino-2,6-dimethoxyquinoxaline (616 mg, 3.00 mmol) and ethyl chloroformate (391 mg, 3.60 mmol) were dissolved in dichloromethane (50 ml) at room temperature and thereto pyridine (285 mg, 3.60 mmol) was added. The resulting mixture was stirred at room temperature for 10 hours and concentrated under the reduced pressure to remove the solvent, and purified by SiO2 column chromatography. Extraction of the residue with a n-hexane:ethyl acetate (3:1) mixture and concentration gave 799 mg of the titled compound (yield, 96%).

1. concentrationconcentrated under the reduced pressure
2. customto remove the solvent
3. custompurified by SiO2 column chromatography
4. extractionExtraction of the residue
5. concentrationwith a n-hexane:ethyl acetate (3:1) mixture and concentration