HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(3-methoxyphenyl)piperazine → 1-[(2,6-Dimethoxyquinoxalin-3-yl)aminocarbonyl]-4-(3-methoxyphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(3-methoxyphenyl)piperazine | HCID 81430 | — |
| Reactant | Ethyl N-(2,6-dimethoxyquinoxalin-3-yl)carbamate | HCID 66918080 | — |
| Product | 1-[(2,6-Dimethoxyquinoxalin-3-yl)aminocarbonyl]-4-(3-methoxyphenyl)piperazine | HCID 66918181 | 80% |
Reaction Steps
Ethyl N-(2,6-dimethoxyquinoxalin-3-yl)carbamate and 1-(3-methoxyphenyl)piperazine were reacted by the same way with the example 64 to obtain the titled compound (yield, 80%). 1H NMR (300 MHz, CDCl3): δ 3.28 (s, 4H), 3.80-3.87 (m, 9H), 4.11 (s, 4H), 6.45-6.49 (m, 2H), 6.56 (d, J=8.4 Hz, 1H), 6.91 (s, 1H), 7.04-7.36 (m, 3H), 7.53-7.62 (m, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08314100B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-7aeddf664f274c3fabe4d9b64d4f89ef |
| Source note | uspto-grants-2012_11 |