2-Mepp → HCID 66918185, compound

HRID 1878169Notes

Reaction equation

HRID 1878169 reaction equation
[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14](=[O:18])OCC)=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:19][CH3:20])[CH:9]=2)[N:4]=1.[CH3:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14]([N:31]2[CH2:32][CH2:33][N:28]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[CH3:21])[CH2:29][CH2:30]2)=[O:18])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:19][CH3:20])[CH:9]=2)[N:4]=1

Participants

3

Reactant 2

HCID 919652-MeppHCID 66918080Ethyl N-(2,6-dimethoxyquinoxalin-3-yl)carbamate

Product 1

HCID 66918185HCID 66918185, compoundYield 90%

Procedure

Ethyl N-(2,6-dimethoxyquinoxalin-3-yl)carbamate and 1-(2-methylphenyl)piperazine were reacted by the same way with the example 64 to obtain the titled compound (yield, 90%). 1H NMR (300 MHz, CDCl3): δ 2.35 (s, 3H), 2.95-3.02 (m, 4H), 3.75-3.90 (m, 6H), 4.09-4.13 (m, 4H), 6.99-7.31 (m, 7H), 7.50-7.66 (m, 1H).

Sources & evidence

ORD record
ord-825870754c764b9b89514db7a2df8ba7
Source dataset
uspto-grants-2012_11
Patent number
US08314100B2

Reaction notes

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