1-(2-Fluorophenyl)piperazine → HCID 66918153, compound

HRID 1878173Notes

Reaction equation

HRID 1878173 reaction equation
[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14](=[O:18])OCC)=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:19][CH3:20])[CH:9]=2)[N:4]=1.[F:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14]([N:31]2[CH2:30][CH2:29][N:28]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[F:21])[CH2:33][CH2:32]2)=[O:18])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:19][CH3:20])[CH:9]=2)[N:4]=1

Participants

3

Reactant 2

HCID 705291-(2-Fluorophenyl)piperazineHCID 66918080Ethyl N-(2,6-dimethoxyquinoxalin-3-yl)carbamate

Product 1

HCID 66918153HCID 66918153, compoundYield 72%

Procedure

Ethyl N-(2,6-dimethoxyquinoxalin-3-yl)carbamate and 1-(2-fluorophenyl)piperazine were reacted by the same way with the example 64 to obtain the titled compound (yield, 72%). 1H NMR (300 MHz, CDCl3): δ 3.18 (s, 4H), 3.73-3.88 (m, 6H), 4.11-4.15 (m, 4H), 6.88-7.15 (m, 5H), 7.33 (s, 1H), 7.51 (d, J=8.7 Hz, 1H), 7.64 (d, J=9.0 Hz, 1H).

Sources & evidence

ORD record
ord-61ee8e619cce4692b6dc5cae00839aa4
Source dataset
uspto-grants-2012_11
Patent number
US08314100B2

Reaction notes

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