1-(2-Fluorophenyl)piperazine → HCID 69243926, compound

HRID 1878196Notes

Reaction equation

HRID 1878196 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13](=[O:17])OCC)[C:6]([O:18][CH3:19])=[N:5]2.[F:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13]([N:30]1[CH2:29][CH2:28][N:27]([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[F:20])[CH2:32][CH2:31]1)=[O:17])[C:6]([O:18][CH3:19])=[N:5]2

Participants

3

Reactant 2

HCID 705291-(2-Fluorophenyl)piperazineHCID 69243333ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate

Product 1

HCID 69243926HCID 69243926, compoundYield 85%

Procedure

Ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate and 1-(2-fluorophenyl)piperazine were reacted by the same way with the example 85 to obtain the titled compound (yield, 85%). 1H NMR (200 MHz, CDCl3): δ 3.17-3.20 (m, 4H), 3.77-3.80 (m, 4H), 4.13 (s, 3H), 6.97-7.09 (m, 4H), 7.24-7.41 (m, 3H), 7.81-7.82 (m, 1H).

Sources & evidence

ORD record
ord-c4cb627661434a7dbda04905a81b36ea
Source dataset
uspto-grants-2012_11
Patent number
US08314100B2

Reaction notes

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