1-(2-Methoxyphenyl)piperazine → HCID 69245249, compound

HRID 1878210Notes

Reaction equation

HRID 1878210 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13](=[O:17])OCC)[C:6]([O:18][CH3:19])=[N:5]2.[CH3:20][O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13]([N:31]1[CH2:30][CH2:29][N:28]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[O:21][CH3:20])[CH2:33][CH2:32]1)=[O:17])[C:6]([O:18][CH3:19])=[N:5]2

Participants

3

Reactant 2

HCID 13461-(2-Methoxyphenyl)piperazineHCID 69241674ethyl N-(6-chloro-3-methoxyquinoxalin-2-yl)carbamate

Product 1

HCID 69245249HCID 69245249, compoundYield 92%

Procedure

Ethyl N-(6-chloro-3-methoxyquinoxalin-2-yl)carbamate and 1-(2-methoxyphenyl)piperazine were reacted by the same way with the example 106 to obtain the titled compound (yield, 92%). 1H NMR (300 MHz, CDCl3): δ 3.17 (s, 4H), 3.82 (s, 4H), 3.89 (s, 3H), 4.15 (s, 3H), 6.89-6.97 (m, 3H), 7.06 (m, 1H), 7.45 (m, 1H), 7.75 (s, 2H).

Sources & evidence

ORD record
ord-e2579504f2ee492f87ad268e0c6a0416
Source dataset
uspto-grants-2012_11
Patent number
US08314100B2

Reaction notes

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