HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Methoxyphenyl)piperazine → 1-[(6-Chloro-3-methoxyquinoxalin-2-yl)aminocarbonyl]-4-(4-methoxyphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Methoxyphenyl)piperazine | HCID 269722 | — |
| Reactant | ethyl N-(6-chloro-3-methoxyquinoxalin-2-yl)carbamate | HCID 69241674 | — |
| Product | 1-[(6-Chloro-3-methoxyquinoxalin-2-yl)aminocarbonyl]-4-(4-methoxyphenyl)piperazine | HCID 69242396 | 90% |
Reaction Steps
Ethyl N-(6-chloro-3-methoxyquinoxalin-2-yl)carbamate and 1-(4-methoxyphenyl)piperazine were reacted by the same way with the example 106 to obtain the titled compound (yield, 90%). 1H NMR (200 MHz, CDCl3): δ 3.17 (s, 4H), 3.78 (s, 7H), 4.15 (m, 3H), 6.85-6.96 (m, 4H), 7.29-7.49 (m, 2H), 7.74-7.77 (m, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08314100B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-53ad5157abc24d65afcb408d1ad3e6a6 |
| Source note | uspto-grants-2012_11 |