1-(2,6-Xylyl)piperazine → HCID 69240978, compound

HRID 1878217Notes

Reaction equation

HRID 1878217 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13](=[O:17])OCC)[C:6]([O:18][CH3:19])=[N:5]2.[CH3:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([CH3:27])[C:22]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13]([N:31]1[CH2:32][CH2:33][N:28]([C:22]3[C:23]([CH3:27])=[CH:24][CH:25]=[CH:26][C:21]=3[CH3:20])[CH2:29][CH2:30]1)=[O:17])[C:6]([O:18][CH3:19])=[N:5]2

Participants

3

Reactant 2

HCID 705381-(2,6-Xylyl)piperazineHCID 69241674ethyl N-(6-chloro-3-methoxyquinoxalin-2-yl)carbamate

Product 1

HCID 69240978HCID 69240978, compoundYield 90%

Procedure

Ethyl N-(6-chloro-3-methoxyquinoxalin-2-yl)carbamate and 1-(2,6-dimethylphenyl)piperazine were reacted by the same way with the example 106 to obtain the titled compound (yield, 90%). 1H NMR (300 MHz, CDCl3): δ 2.36 (s, 3H), 3.14 (s, 4H), 3.70 (s, 4H), 4.15 (s, 3H), 6.95-7.01 (m, 3H), 7.26-7.46 (m, 3H), 7.61-7.81 (m, 2H).

Sources & evidence

ORD record
ord-da1fd34332544d809a0d629d52fabb6c
Source dataset
uspto-grants-2012_11
Patent number
US08314100B2

Reaction notes

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