1-(2-Chlorophenyl)piperazine → HCID 69242717, compound

HRID 1878244Notes

Reaction equation

HRID 1878244 reaction equation
[CH3:1][O:2][C:3]1[C:4]([NH:14][C:15](=[O:19])OCC)=[N:5][C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([CH3:13])=[CH:8][CH:7]=2.[Cl:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[CH3:1][O:2][C:3]1[C:4]([NH:14][C:15]([N:30]2[CH2:29][CH2:28][N:27]([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[Cl:20])[CH2:32][CH2:31]2)=[O:19])=[N:5][C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([CH3:13])=[CH:8][CH:7]=2

Participants

3

Reactant 2

HCID 4156281-(2-Chlorophenyl)piperazineHCID 69243736ethyl N-(3-methoxy-6-methylquinoxalin-2-yl)carbamate

Product 1

HCID 69242717HCID 69242717, compoundYield 85%

Procedure

Ethyl N-(3-methoxy-6-methylquinoxalin-2-yl)carbamate and 1-(2-chlorophenyl)piperazine were reacted by the same way with the example 127 to obtain the titled compound (yield, 85%). 1H NMR (300 MHz, CDCl3): δ 2.49 (s, 3H), 3.08-3.17 (m, 4H), 3.73-3.86 (m, 4H), 4.13 (s, 3H), 7.00-7.65 (m, 7H), 7.74 (d, J=8.0 Hz, 1H).

Sources & evidence

ORD record
ord-159e10cad93a438bbd233474cf76f795
Source dataset
uspto-grants-2012_11
Patent number
US08314100B2

Reaction notes

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