1-(2-Pyrimidinyl)piperazine → 1-[(3-Methoxy-6-methylquinoxalin-2-yl)aminocarbonyl]-4-(2-pyrimidyl)piperazine

Participants

Reaction Steps

Ethyl N-(3-methoxy-6-methylquinoxalin-2-yl)carbamate and 1-(2-pyrimidyl)piperazine were reacted by the same way with the example 127 to obtain the titled compound (yield, 79%). 1H NMR (300 MHz, CDCl3): δ 2.45 (s, 3H), 3.60-3.80 (m, 4H), 3.80-4.05 (m, 4H), 4.13 (s, 3H), 6.52 (t, J=4.5 Hz, 1H), 7.00-7.69 (m, 4H), 8.32 (d, J=4.5 Hz, 2H).

Provenance & Evidence