1-(2-Fluorophenyl)piperazine → HCID 69243942, compound

HRID 1878264Notes

Reaction equation

HRID 1878264 reaction equation
[CH3:1][O:2][C:3]1[C:4]([NH:15][C:16](=[O:20])OCC)=[N:5][C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([O:13][CH3:14])=[CH:8][CH:7]=2.[F:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[CH3:1][O:2][C:3]1[C:4]([NH:15][C:16]([N:31]2[CH2:30][CH2:29][N:28]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[F:21])[CH2:33][CH2:32]2)=[O:20])=[N:5][C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([O:13][CH3:14])=[CH:8][CH:7]=2

Participants

3

Reactant 2

HCID 705291-(2-Fluorophenyl)piperazineHCID 69244324ethyl N-(3,6-dimethoxyquinoxalin-2-yl)carbamate

Product 1

HCID 69243942HCID 69243942, compoundYield 95%

Procedure

Ethyl N-(3,6-dimethoxyquinoxalin-2-yl)carbamate and 1-(2-fluorophenyl)piperazine were reacted by the same way with the example 148 to obtain the titled compound (yield, 95%). 1H NMR (300 MHz, CDCl3): δ 3.18 (s, 4H), 3.66 (s, 4H), 3.78 (s, 3H), 4.15 (s, 3H), 6.94-7.27 (m, 7H), 7.73-7.87 (m, 1H).

Sources & evidence

ORD record
ord-000624ebd5094ea8bac433eff4e0274a
Source dataset
uspto-grants-2012_11
Patent number
US08314100B2

Reaction notes

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