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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1878301Generated: November 2, 2026

1-(3,5-Dimethoxyphenyl)piperazine → 1-[(2,6,7-Trimethoxyquinoxalin-3-yl)aminocarbonyl]-4-(3,5-dimethoxyphenyl)piperazine

https://huagongshe.com/reaction/1878301

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(3,5-Dimethoxyphenyl)piperazineHCID 2736205—
ReactantEthyl N-(2,6,7-trimethoxyquinoxalin-3-yl)carbamateHCID 69244380—
Product1-[(2,6,7-Trimethoxyquinoxalin-3-yl)aminocarbonyl]-4-(3,5-dimethoxyphenyl)piperazineHCID 6924588268%

Reaction Steps

Ethyl N-(2,6,7-trimethoxyquinoxalin-3-yl)carbamate and 1-(3,5-dimethoxyphenyl)piperazine were reacted by the same way with the example 190 to obtain the titled compound (yield, 68%). 1H NMR (300 MHz, CDCl3) δ 3.28-3.29 (m, 4H), 3.75-3.79 (m, 4H), 3.97 (s, 3H), 4.00 (s, 3H), 4.13 (s, 3H), 6.07-6.11 (m, 3H), 7.14 (s, 1H), 7.27-7.28 (m, 2H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08314100B2
Source datasetuspto-grants-2012_11
ORD IDord-539b4b9c001741d2a3ddc2e7c181c99c
Source noteuspto-grants-2012_11