Triethylamine → N-tert-Butyl-3-((4-(4-(cyclohexanecarboxamido)-3-fluorobenzoyl)piperazin-1-yl)methyl)-benzamide

Participants

Reaction Steps

To a stirred solution of 3-((4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide (0.121 mmol, 50 mg) and triethylamine (0.485 mmol, 0.068 mL, 49.1 mg) in dichloromethane (1.5 mL) was added cyclohexanecarbonyl chloride (0.133 mmol, 19.55 mg). After 16 hours stirring, the reaction was concentrated under vacuum and purified by acidic reverse phase HPLC to yield the title compound (28 mg).

Provenance & Evidence