2-Fluorophenyl isocyanate → N-tert-Butyl-3-((4-(3-fluoro-4-(3-(2-fluorophenyl)ureido)benzoyl)piperazin-1-yl)methyl)benzamide

Participants

Reaction Steps

3-((4-(4-Amino-3-fluorobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide (100 mg, 0.242 mmol) and 2-fluorophenylisocyanate (37 mg, 0.267 mmol) were combined and heated in dichloromethane at 100° C. in the microwave for 10 minutes. The solvent was removed under reduced pressure and the residue purified by acidic reverse phase HPLC to afford the title compound (12 mg).

Provenance & Evidence