Cyclobutylamine → HCID 25191378, compound

Participants

Reaction Steps

3-((4-(4-Amino-3-chlorobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide (200 mg, 0.466 mmol) and 4-nitrophenylchloroformate (94 mg, 0.466 mmol) were heated to reflux in dichloromethane (10 ml) for 2 hours. Cyclobutylamine (99 mg, 1.398 mmol) was added and the reaction stirred overnight. The reaction mixture was washed with water, dried over sodium sulfate and concentrated under vacuum. The resulting residue was purified by acidic reverse phase HPLC to afford the title compound (20 mg).

Provenance & Evidence