Neopentylamine → HCID 57917620, compound

Participants

Reaction Steps

3-((4-(4-Amino-2-methylbenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide (100 mg, 0.24 mmol) and 4-nitrophenylchloroformate (49 mg, 0.24 mmol) were stirred in dichloromethane (2 mL) for 30 minutes. Neopentylamine (64 mg, 0.73 mmol) was added and the reaction stirred at room temperature for 2 hours. The reaction was concentrated under vacuum. The resulting residue was purified by acidic reverse phase HPLC to afford the title compound (31 mg). MS (ESI) m/z 522.7 [M+H]+

Provenance & Evidence