HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Difluoro-4-nitrobenzoic acid → 4-Amino-2,5-difluorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Difluoro-4-nitrobenzoic acid | HCID 246375 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Amino-2,5-difluorobenzoic acid | HCID 20151477 | 93.1% |
Reaction Steps
2,5-Difluoro-4-nitrobenzoic acid (1 g, 4.9 mmol) was dissolved in ethanol. 10% Palladium on carbon (500 mg) was added and reaction stirred under a hydrogen balloon overnight. The catalyst was filtered off and the filtrate was concentrated under reduced pressure to afford the title compound (0.79 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08314091B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-423023a757794deabda7a50b2aff2ab5 |
| Source note | uspto-grants-2012_11 |