Triethylamine → HCID 57917707, compound

Participants

Reaction Steps

To a stirred solution, of. 4-amino-3-methylbenzoic acid (3.31 mmol, 0.50 g), N-tert-butyl-3-(piperazin-1-ylmethyl)benzamide (3.45 mmol, 0.95 g) and triethylamine (14.35 mmol, 2.00 mL, 1.452 g) in dichloromethane (10 mL) was added 1-propanephosphonic acid cyclic anhydride (6.75 mmol, 4 mL, 4.30 g, 50% in ethyl acetate) dropwise. The mixture was allowed to stir for 1 hour. After this time ethyl acetate was added and the organic mixture was washed with saturated sodium hydrogen carbonate (×2), water (×2) and finally brine. The organic layer was dried with sodium sulfate and concentrated under vacuum to yield the title compound (0.60 g).

Provenance & Evidence