Neopentylamine → HCID 57917639, compound

Participants

Reaction Steps

To a stirred solution of 3-((4-(4-amino-3-methylbenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide (0.153 mmols 62.5 mg) in dichloromethane (2 mL) was added 4-nitrophenylchloroformate (0,153 mmol, 30.8 mg). After 1 hour stirring, 2,2-dimethylpropan-1-amine (0.306 mmol, 26.7 mg) was added and stirring continued for 1 hour. The reaction was concentrated under vacuum and the residue dissolved in methanol (1 mL). Purification by basic reverse phase HPLC gave the title compound (11.5 mg).

Provenance & Evidence