Neopentylamine → HCID 57917621, compound

Participants

Reaction Steps

To a stirred solution of 3-((4-(4-amino-2-(trifluoromethyl)benzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide (0.123 mmol, 57 mg) in dichloromethane (2 mL) was added 4-nitrophenylchloroformate (0.123 mmol, 24.84 mg). After 1 hour stirring, 2,2-dimethylpropan-1-amine (0.123 mmol, 10.74 mg) was added and stirring was continued for 1 hour. The reaction was concentrated under reduced pressure and the residue dissolved in methanol (1 mL). Purification by basic reverse phase HPLC gave the title compound (27 mg).

Provenance & Evidence