tert-Butanol → HCID 66878222, compound

HRID 1878373Notes

Reaction equation

HRID 1878373 reaction equation
N([C:4]([C:6]1[N:7]=[CH:8][C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[N:10][CH:11]=1)=[O:5])=[N+]=[N-].[C:17]([OH:21])([CH3:20])([CH3:19])[CH3:18]>C1(C)C=CC=CC=1>[C:17]([O:21][C:4]([C:6]1[N:7]=[CH:8][C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[N:10][CH:11]=1)=[O:5])([CH3:20])([CH3:19])[CH3:18]

Participants

4

Reactant 2

HCID 6386tert-ButanolHCID 86635133HCID 86635133, compound

Product 1

HCID 66878222HCID 66878222, compoundYield 65.8%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of ethyl 5-(azidocarbonyl)pyrazine-2-carboxylate (1.00 g, 4.52 mmol), tert-butanol (1.5 mL, 20.2 mmol) and toluene (15 mL) was heated to reflux for 1 hour. After cooling to room temperature, the solid precipitate was collected to afford the title compound (0.75 g).

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 1 hour
  3. customthe solid precipitate was collected

Sources & evidence

ORD record
ord-c2486f7ba3c04cbeba5dd5ad265c901f
Source dataset
uspto-grants-2012_11
Patent number
US08314091B2

Reaction notes

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