Trifluoroacetic acid → HCID 57917610, compound

Participants

Reaction Steps

A mixture of tert-butyl 5-(1-(3-(tert-butylcarbamoyl)benzyl)piperazine-4-carbonyl)pyrazin-2-ylcarbamate (Example 30;120 mg, 0.242 mmol), dichloromethane (2 mL) and trifluoroacetic acid (2 mL) was stirred at room temperature for 3 hours and was then concentrated under vacuum. The residue was triturated with diethyl ether and then gravity filtered over fluted paper. The collected solid was partitioned between ethyl acetate and saturated aqueous sodium hydrogen carbonate. The aqueous layer was separated and extracted with ethyl acetate. The combined organic layers were dried over magnesium sulfate, filtered and concentrated under vacuum to afford the title compound (89 mg). MS (ESI) m/z 397.2 [M-+H]+

Provenance & Evidence