HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclobutylamine → Ethyl 4-(3-cyclobutylureido)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclobutylamine | HCID 75645 | — |
| Reactant | Ethyl 4-isocyanatobenzoate | HCID 589805 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 4-(3-cyclobutylureido)benzoate | HCID 4353410 | 88.3% |
Reaction Steps
Cyclobutylamine (27.91 g, 392.4 mmol, 33.5 mL) was added dropwise to a stirred solution of ethyl 4-isocyanatobenzoate (25 g, 130.8 mmol) in dichloromethane. After 40 minutes stirring, the solid precipitate that had formed was filtered off and dried to afford the title compound (30.28 g). MS (ESI) m/z 263.1 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08314091B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-674a9c16d3984421b1780dd87c52f72a |
| Source note | uspto-grants-2012_11 |