Hydrochloric Acid → (S)-1-Cyclobutyl 3-(4-(2-methylpiperazine-1-carbonyl)phenyl)urea hydrochloride

Participants

Reaction Steps

tert-Butyl 4-(4-(3-cyclobutylureido)benzoyl)-3-methylpiperazine-1-carboxylate (0.20 g, 0.48 mmol) was treated with an ethanolic solution of hydrochloric acid (2 mL, 14.5 wt % hydrochloric acid in ethanol). The resultant mixture was stirred at room temperature for 2 hours. The mixture was concentrated under vacuum, azeotroped with dichloromethane (×2) and dried under vacuum to afford the title compound (0.152 g) as a white foamy solid. MS (ESI) m/z 317.0 [M+H]+

Provenance & Evidence