HCID 57917668, compound → HCID 57917674, compound

HRID 1878383Notes

Reaction equation

HRID 1878383 reaction equation
[C:1]([NH:5][C:6]([C:8]1[CH:9]=[C:10]([CH:26]=[CH:27][CH:28]=1)[CH2:11][N:12]1[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][C@H:13]1[CH3:25])=[O:7])([CH3:4])([CH3:3])[CH3:2]>ClCCl.FC(F)(F)C(O)=O>[C:1]([NH:5][C:6](=[O:7])[C:8]1[CH:28]=[CH:27][CH:26]=[C:10]([CH2:11][N:12]2[CH2:17][CH2:16][NH:15][CH2:14][C@H:13]2[CH3:25])[CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 57917668HCID 57917668, compound

Product 1

HCID 57917674HCID 57917674, compoundYield 51.3%

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

(R)-tert-Butyl 4-(3-(tert-butylcarbamoyl)benzyl)-3-methylpiperazine-1-carboxylate (8.03 g, 20.61 mmol) was stirred in a mixture of dichloromethane:trifluoroacetic acid (1:1) for 2 hours. The reaction mixture was concentrated under vacuum and purified by strong cation exchange column chromatography to afford the title compound (3.06 g).

Workup

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. custompurified by strong cation exchange column chromatography

Sources & evidence

ORD record
ord-bb85955515de4a6082e84652f439aa0a
Source dataset
uspto-grants-2012_11
Patent number
US08314091B2

Reaction notes

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