Water → HCID 57917713, compound

Participants

Reaction Steps

(R)-3-((4-(4-Amino-3-fluorobenzoyl)-2-methylpiperazin-1-yl)methyl)-N-tert-butylbenzamide (119 mg, 0.275 mmol) and 4-nitrophenol chloroformate (56 mg, 0.275 mmol) were combined and stirred in dichloromethane for 1 hour. Cyclopropanemethylamine (56.8 mg, 0.8 mmol, 0.0694 mL) was added and the reaction was stirred for a further 30 minutes. Water was added and the reaction mixture was flushed through a hydrophobic frit. The organic phase was concentrated under reduced pressure and purified by basic reverse phase HPLC to afford the title compound (19.8 mg). MS (ES) m/z 524.7 [M+H]+

Provenance & Evidence