Cyclobutylamine → HCID 57917682, compound

Participants

Reaction Steps

To 3-((4-(4-amino-3-fluorobenzoyl)-2,2-dimethylpiperazin-1-yl)methyl)-N-tert-butylbenzamide (0.1 mmol, 45 mg) in dichloromethane (1.5 mL) was added 4-nitrophenyl chloroformate (0.11 mmol, 23 mg). The mixture was allowed to stir for 2 hours before the addition of cyclobutylamine (1.757 mmol, 125 mg, 150 μl). The mixture was allowed to stir for a further 16 hours before being concentrated under vacuum and purified by acidic reverse phase HPLC. The free base of the product was obtained using strong cation exchange column chromatography. This material was lyophilised to yield the title compound (16 mg).

Provenance & Evidence