Methanesulfonyl chloride → HCID 86635134, compound

Participants

Reaction Steps

A solution of methanesulfonyl chloride (165 mg, 1.44 mmol) in dichloromethane (2.0 mL) was added to a stirred solution of N-tert-butyl-3-(1-hydroxy-2-methylpropyl)benzamide (300 mg, 1.20 mmol) in dichloromethane (8.0 mL). After 1.5 hours stirring, the mixture was partitioned between dichloromethane and aqueous sodium hydrogen carbonate solution. The aqueous layer was extracted with dichloromethane and the combined organic layers were washed with brine, dried over sodium sulfate and concentrated under vacuum to afford the intermediate 1-(3-(tert-butylcarbamoyl)phenyl)propyl methanesulfonate.

Provenance & Evidence