反应详情

3((4-(4-Aminobenzoyl)piperazin-1-yl)methyl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)benzamide (0.129 mmol, 58 mg) and 4-nitrophenylchloroformate (0.142 mmol, 29 mg) were stirred together in dichloromethane (1 mL) for 16 hours. After this time neopentylamine (0.259 mmol, 32 μL) was added. The volatiles were removed under vacuum and this residue was purified by silica chromatography to yield the title compound (50 mg). MS (ESI) m/z 562.5 [M+H]+

1. customThe volatiles were removed under vacuum
2. customthis residue was purified by silica chromatography