Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | HCID 62414168 | HCID 62414168 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 57917626 | HCID 57917626 | 98.8% |
Reaction Steps
A stirred suspension of tert-butyl piperazine-1-carboxylate (8.94 mmol, 1.665 g), 3-(chloromethyl)-N-cyclobutylbenzamide (8.94 mmol, 2 g), potassium carbonate (17.88 mmol, 2.471 g) and sodium iodide (0.894 mmol, 0.134 g) in acetonitrile (50 ml) was heated at 80° C. for 3 hours. The reaction mixture was diluted with ethyl acetate and water. The organic layer was separated, dried (magnesium sulfate) and concentrated under reduced pressure to give the title compound (3.3 g). MS (ESI) m/z 374.4 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08314091B2 |
|---|
| Source dataset | uspto-grants-2012_11 |
|---|
| ORD ID | ord-6f73795f1e5e4f6cb6f4a38902a5d24e |
|---|
| Source note | uspto-grants-2012_11 |
|---|
