Trifluoroacetic acid → HCID 57917592, compound

Participants

Reaction Steps

To a stirred solution of tert-butyl 4-(3-(cyclobutylcarbamoyl)benzyl)piperazine-1-carboxylate (8.84 mmol, 3.3 g) in dichloromethane (10 mL) was added trifluoroacetic acid (5 ml). The reaction mixture was stirred for 24 hours then concentrated under reduced pressure. Purification by strong cation exchange column chromatography gave the title compound (2.4 g). MS (ESI) m/z 274.5 [M+H]+

Provenance & Evidence