Neopentylamine → HCID 25191885, compound

Participants

Reaction Steps

To a stirred solution of bis(trichloromethyl) carbonate (0.331 mmol, 98 mg) in dichloromethane (10 mL) was added a solution of 3-((4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)methyl)-N-cyclobutylbenzamide (0.974 mmol, 400 mg) and N-ethyl-N-isopropylpropan-2-amine (2.144 mmol, 0.354 mL, 277 mg) in dichloromethane (10 mL) (dropwise). The reaction mixture was stirred for 1 hour then 2,2-dimethylpropan-1-amine (1.169 mmol, 0.137 mL, 102 mg) was added. The reaction mixture was stirred for 20 hours. Chromatography on silica (eluting with dichloromethane to dichloromethane/methanol (1% to 3%)) gave the title compound (266 mg).

Provenance & Evidence