Ethyl 6-iodoimidazo[1,2-a]pyridine-2-carboxylate → 6-iodo-N-phenylimidazo[1,2-a]pyridine-2-carboxamide

HRID 1878470Notes

Reaction equation

HRID 1878470 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([NH:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[O:12])[N:10]=2)[CH:7]=1.[I:20]C1C=CC2N(C=C(C(OCC)=O)N=2)C=1>>[I:20][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([NH:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[O:12])[N:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 3681971Ethyl 6-iodoimidazo[1,2-a]pyridine-2-carboxylateHCID 247716736-bromo-N-phenylimidazo[1,2-a]pyridine-2-carboxamide

Product 1

HCID 441359396-iodo-N-phenylimidazo[1,2-a]pyridine-2-carboxamide

Procedure

By working in the same manner as for the preparation of Intermediate 1, replacing the ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate with ethyl 6-iodoimidazo[1,2-a]pyridine-2-carboxylate, 6-iodo-N-phenylimidazo[1,2-a]pyridine-2-carboxamide is obtained in the form of a beige-coloured solid.

Sources & evidence

ORD record
ord-80fac43816284c88a464200adbd18c09
Source dataset
uspto-grants-2012_11
Patent number
US08314109B2

Reaction notes

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